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Details on Person UniProt:O00268 TAF4
| Class:Id | ReferenceGeneProduct:212205 |
|---|---|
| _chainChangeLog | chain:1-1085 added on Fri February 6 2015 |
| _displayName | UniProt:O00268 TAF4 |
| _timestamp | 2025-02-21 20:04:31 |
| chain | chain:1-1085 |
| checksum | BC2F5B5F143DB145 |
| comment | FUNCTION The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867).SUBUNIT Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10, TAF12 and TRRAP (PubMed:10373431, PubMed:12601814). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation (PubMed:15735663).SUBUNIT (Microbial infection) Interacts with SV40 Large T antigen.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TAF4 family. |
| created | [InstanceEdit:212200] Caudy, M, 2008-02-08 20:35:02 |
| description | recommendedName: Transcription initiation factor TFIID subunit 4 alternativeName: RNA polymerase II TBP-associated factor subunit C alternativeName: TBP-associated factor 4 alternativeName: Transcription initiation factor TFIID 130 kDa subunit shortName: TAF(II)130 shortName: TAFII-130 shortName: TAFII130 alternativeName: Transcription initiation factor TFIID 135 kDa subunit shortName: TAF(II)135 shortName: TAFII-135 shortName: TAFII135 |
| geneName | TAF4 TAF2C TAF2C1 TAF4A TAFII130 TAFII135 |
| identifier | O00268 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disease variant Host-virus interaction Intellectual disability Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | TAF4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999191] ENSEMBL:ENSG00000130699 TAF4 [Homo sapiens] |
| secondaryIdentifier | TAF4_HUMAN A6NGD9 Q5TBP6 Q99721 Q9BR40 Q9BX42 |
| sequenceLength | 1085 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:65541] TAF4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:212396] TAF4 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O00268 TAF4 (212205)
