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Details on Person UniProt:Q9Y6J9 TAF6L
| Class:Id | ReferenceGeneProduct:212203 |
|---|---|
| _chainChangeLog | chain:1-622 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y6J9 TAF6L |
| _timestamp | 2026-02-20 23:00:54 |
| chain | chain:1-622 |
| checksum | F294E71AF7D4C8C3 |
| comment | FUNCTION Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity).SUBUNIT The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.SUBCELLULAR LOCATION Belongs to the TAF6 family. |
| created | [InstanceEdit:212200] Caudy, M, 2008-02-08 20:35:02 |
| description | recommendedName: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L shortName evidence="6"TAF6L alternativeName: PCAF-associated factor 65-alpha shortName: PAF65-alpha |
| geneName | TAF6L PAF65A |
| identifier | Q9Y6J9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TAF6L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992181] ENSEMBL:ENSG00000162227 TAF6L [Homo sapiens] |
| secondaryIdentifier | TAF6L_HUMAN B2RAT0 Q96HA6 |
| sequenceLength | 622 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:212393] TAF6L [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y6J9 TAF6L (212203)
