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Details on Person UniProt:Q15543 TAF13
| Class:Id | ReferenceGeneProduct:212201 |
|---|---|
| _chainChangeLog | chain:1-124 added on Sat February 7 2015 |
| _displayName | UniProt:Q15543 TAF13 |
| _timestamp | 2024-11-03 20:03:30 |
| chain | chain:1-124 |
| checksum | 98B62FF1BC8E7B77 |
| comment | FUNCTION The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473, PubMed:9695952). TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473).SUBUNIT Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Interacts with TBP, and more strongly with TAF10 and TAF11 (PubMed:9695952).INTERACTION The binding of TAF10 and TAF11 requires distinct domains of TAF13.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TAF13 family. |
| created | [InstanceEdit:212200] Caudy, M, 2008-02-08 20:35:02 |
| description | recommendedName: fullName evidence="8"Transcription initiation factor TFIID subunit 13 alternativeName: fullName evidence="6"Transcription initiation factor TFIID 18 kDa subunit shortName evidence="7"TAF(II)18 shortName evidence="8"TAFII-18 shortName evidence="6"TAFII18 |
| geneName | TAF13 TAF2K TAFII18 |
| identifier | Q15543 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant Intellectual disability Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TAF13 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989257] ENSEMBL:ENSG00000197780 TAF13 [Homo sapiens] |
| secondaryIdentifier | TAF13_HUMAN B2R5E5 Q5TYV6 |
| sequenceLength | 124 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:65557] TAF13 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:212397] TAF13 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q15543 TAF13 (212201)
