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Details on Person UniProt:Q53T94 TAF1B
| Class:Id | ReferenceGeneProduct:212191 |
|---|---|
| _chainChangeLog | chain:1-588 added on Fri February 6 2015 |
| _displayName | UniProt:Q53T94 TAF1B |
| _timestamp | 2024-11-03 20:21:47 |
| chain | chain:1-588 |
| checksum | CE45DE622E28FD6E |
| comment | FUNCTION Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.SUBUNIT Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3. Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex.INTERACTION Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (PubMed:21921198, PubMed:21921199).SIMILARITY Belongs to the RRN7/TAF1B family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:212200] Caudy, M, 2008-02-08 20:35:02 |
| description | recommendedName: TATA box-binding protein-associated factor RNA polymerase I subunit B alternativeName: RNA polymerase I-specific TBP-associated factor 63 kDa shortName: TAFI63 alternativeName: TATA box-binding protein-associated factor 1B shortName: TBP-associated factor 1B alternativeName: Transcription initiation factor SL1/TIF-IB subunit B |
| geneName | TAF1B |
| identifier | Q53T94 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Direct protein sequencing DNA-binding Metal-binding Nucleus Proteomics identification Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TAF1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003860] ENSEMBL:ENSG00000115750 TAF1B [Homo sapiens] |
| secondaryIdentifier | TAF1B_HUMAN B4DI42 F8WD72 Q15574 Q8WVC3 |
| sequenceLength | 588 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:250384] UniProt:Q53T94-2 TAF1B [Homo sapiens] [ReferenceIsoform:406971] UniProt:Q53T94-1 TAF1B [Homo sapiens] [ReferenceIsoform:8970766] UniProt:Q53T94-3 TAF1B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:73691] TAF1B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:212348] TAF1B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5138530] Ac-TAF1B [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:5138539] N6-acetyl-L-lysine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q53T94 TAF1B (212191)
