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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person DNMT1 [nucleoplasm]

Class:IdEntityWithAccessionedSequence:212181
_displayNameDNMT1 [nucleoplasm]
_timestamp2014-11-20 03:23:10
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:212086] May, B, Gopinathrao, G, 2008-02-08 19:50:06
endCoordinate1616
modified[InstanceEdit:417205] May, B, 2009-04-12 08:40:21
[InstanceEdit:3132750] Wu, G, 2013-02-13
nameDNMT1
referenceEntity[ReferenceGeneProduct:403470] UniProt:P26358 DNMT1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5646281] R-HSA-212181.1
startCoordinate1
(activeUnit)[NegativeGeneExpressionRegulation:9850955] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9850965] Negative gene expression regulation by 'DNMT1 [nucleoplasm]'
[NegativeGeneExpressionRegulation:9850971] Negative gene expression regulation by 'pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm]'
[CatalystActivity:212175] DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates of Heterochromatin Replication Complex [nucleoplasm]
[CatalystActivity:5334139] DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates of DNMT1:UHRF1:Chromatin with hemimethylC [nucleoplasm]
(hasComponent)[Complex:212059] DNMT1:G9a [nucleoplasm] [Homo sapiens]
[Complex:212159] DNMT1:UHRF1:hemimethylated DNA [nucleoplasm] [Homo sapiens]
[Complex:427410] NoRC:pRNA:HDAC:DNMT [nucleoplasm] [Homo sapiens]
[Complex:5334177] DNMT1:UHRF1:symmetrically methylated DNA [nucleoplasm] [Homo sapiens]
[Complex:9850883] DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm] [Homo sapiens]
[Complex:9850934] p-Y705, S727 STAT3 dimer:DNMT1:ZAP70 gene [nucleoplasm] [Homo sapiens]
[Complex:9850942] pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] [Homo sapiens]
(hasMember)[DefinedSet:212315] DNMT1,3A,3B [nucleoplasm] [Homo sapiens]
(input)[Reaction:427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA [Homo sapiens]
[Reaction:4655431] SUMOyation of DNMT1 with SUMO1 [Homo sapiens]
[Reaction:5334160] UHRF1:Chromatin binds DNMT1 [Homo sapiens]
[Reaction:9851058] AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene [Homo sapiens]
[Reaction:9851071] STAT3, DNMT1 and HDAC1 bind PTPN6 gene [Homo sapiens]
(output)[BlackBoxEvent:5660531] Expression of DNMT1 [Homo sapiens]
[BlackBoxEvent:9851145] Translation of DNMT1 mRNA is repressed by miR-21 [Homo sapiens]
(regulator)[NegativeGeneExpressionRegulation:9850965] Negative gene expression regulation by 'DNMT1 [nucleoplasm]'
(requiredInputComponent)[Reaction:9817458] TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3 [Homo sapiens]
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No pathways have been reviewed or authored by DNMT1 [nucleoplasm] (212181)
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