Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person CYP26A1,B1 4-hydroxylate atRA

Class:IdReaction:212007
_displayNameCYP26A1,B1 4-hydroxylate atRA
_doReleaseTRUE
_timestamp2014-06-23 14:46:06
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:5362526] retinoic acid 4-hydroxylase activity of CYP26A1,B1,C1 [endoplasmic reticulum membrane]
compartment[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:211969] Jassal, B, 2008-02-08 15:33:52
edited[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
input[SimpleEntity:215573] atRA [endoplasmic reticulum lumen]
[SimpleEntity:113601] NADPH [endoplasmic reticulum lumen]
[SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
[SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
literatureReference[LiteratureReference:215603] Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells
[LiteratureReference:215645] Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism
modified[InstanceEdit:215585] Jassal, B, 2008-03-06 14:26:56
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351777] Jassal, B, 2008-05-28 08:44:17
[InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30
[InstanceEdit:5362527] Jassal, Bijay, 2014-04-16
[InstanceEdit:5545499] Jassal, Bijay, 2014-05-22
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCYP26A1,B1 4-hydroxylate atRA
output[SimpleEntity:215584] 4OH-atRA [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
[SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen]
releaseDate2008-06-30
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359883] R-HSA-212007.2
summation[Summation:215595] Retinoic acid (RA) is a biologically active analogue of vita...
(hasEvent)[Pathway:211916] Vitamins [Homo sapiens]
(normalReaction)[FailedReaction:5602063] Defective CYP26B1 does not 4-hydroxylate atRA [Homo sapiens]
(replacementInstances)[_Deleted:5545501] Deletion of instance: 211930
(updatedInstance)[_UpdateTracker:9785974] Update Tracker - [Reaction:212007] CYP26A1,B1 4-hydroxylate atRA - v50:[modifyText]
[_UpdateTracker:9786614] Update Tracker - [Reaction:212007] CYP26A1,B1 4-hydroxylate atRA - v49:[addLiteratureReference, add_removeCatalystActivity, modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by CYP26A1,B1 4-hydroxylate atRA (212007)
Follow Reactome