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Details on Person CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation

Class:IdReaction:211988
_displayNameCYP2C9 inactivates tolbutamide by 4methyl-hydroxylation
_doReleaseTRUE
_timestamp2023-08-22 22:22:11
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:211992] monooxygenase activity of Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane]
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:17957] endoplasmic reticulum lumen
created[InstanceEdit:211969] Jassal, B, 2008-02-08 15:33:52
edited[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
input[SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
[SimpleEntity:113601] NADPH [endoplasmic reticulum lumen]
[SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
[ChemicalDrug:9838902] TBM [endoplasmic reticulum lumen]
literatureReference[LiteratureReference:211920] Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9
modified[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351777] Jassal, B, 2008-05-28 08:44:17
[InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:2656455] D'Eustachio, P, 2012-11-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9838903] D'Eustachio, Peter, 2023-06-27
[InstanceEdit:9842210] Matthews, Lisa, 2023-08-22
nameCYP2C9 inactivates tolbutamide by 4methyl-hydroxylation
output[SimpleEntity:211937] HTOLB [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
[SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen]
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2008-06-30
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
[InstanceEdit:9842118] D'Eustachio, Peter, 2023-08-18
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9838901] D'Eustachio, Peter, 2023-06-27
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360170] R-HSA-211988.3
structureModified[InstanceEdit:9838903] D'Eustachio, Peter, 2023-06-27
summation[Summation:211883] Tolbutamide is an oral hypoglycemic agent whose action is te...
(hasEvent)[Pathway:211981] Xenobiotics [Homo sapiens]
(updatedInstance)[_UpdateTracker:9842320] Update Tracker - [Reaction:211988] CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation - v86:[add_removeInput]
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No pathways have been reviewed or authored by CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (211988)