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Details on Person CYP4F2, 4F3 20-hydroxylate LTB4

Class:Id	Reaction:211873
_displayName	CYP4F2, 4F3 20-hydroxylate LTB4
_doRelease	TRUE
_timestamp	2024-07-17 18:27:48
authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:2162138] leukotriene-B4 20-monooxygenase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:211969] Jassal, B, 2008-02-08 15:33:52
crossReference	[DatabaseIdentifier:9915860] RHEA:22177
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
input	[SimpleEntity:266056] LTB4 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:215515] Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4 [LiteratureReference:215553] Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization
modified	[InstanceEdit:215522] Jassal, B, 2008-03-04 14:20:48 [InstanceEdit:350661] Jassal, Bijay, 2008-05-20 [InstanceEdit:351777] Jassal, B, 2008-05-28 08:44:17 [InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30 [InstanceEdit:500338] Jassal, B, 2010-02-03 [InstanceEdit:571356] D'Eustachio, P, 2010-04-09 [InstanceEdit:2162166] Williams, MG, 2012-03-14 [InstanceEdit:2201180] Williams, MG, 2012-04-17 [InstanceEdit:2569041] D'Eustachio, P, 2012-11-10 [InstanceEdit:5602279] Jassal, Bijay, 2014-06-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915866] D'Eustachio, Peter, 2024-07-17
name	CYP4F2, 4F3 20-hydroxylate LTB4 leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it
output	[SimpleEntity:2161636] 20OH-LTB4 [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:266072] LTA4 is hydolysed to LTB4 by LTA4H [Homo sapiens] [Reaction:266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361320] R-HSA-211873.3
summation	[Summation:215523] Leukotriene B4 (LTB4) is formed from arachidonate and is a p...
(hasEvent)	[Pathway:211979] Eicosanoids [Homo sapiens] [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Homo sapiens]
(precedingEvent)	[Reaction:2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786335] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v50:[modifyText] [_UpdateTracker:9788705] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v41:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9790415] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v33:[addOutput] [_UpdateTracker:9919468] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v90:[modifyText]
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No pathways have been reviewed or authored by CYP4F2, 4F3 20-hydroxylate LTB4 (211873)