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Details on Person Stimulation of cell death by PAK-2 requires the generation ...

Class:IdSummation:211770
_displayNameStimulation of cell death by PAK-2 requires the generation ...
_timestamp2008-02-29 19:32:29
created[InstanceEdit:211772] Matthews, L, 2008-02-08 13:09:48
literatureReference[LiteratureReference:211630] Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity
[LiteratureReference:211655] Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation
modified[InstanceEdit:211776] Matthews, L, 2008-02-08 13:18:56
[InstanceEdit:211780] Matthews, L, 2008-02-08 14:00:30
[InstanceEdit:213328] Matthews, L, 2008-02-25 12:55:56
[InstanceEdit:215514] Matthews, L, 2008-02-29 19:31:36
textStimulation of cell death by PAK-2 requires the generation and stabilization of the caspase-activated form, PAK-2p34 (Walter et al., 1998;Jakobi et al., 2003). Levels of proteolytically activated PAK-2p34 protein are controlled by ubiquitin-mediated proteolysis. PAK-2p34 but not full-length PAK-2 is degraded by the 26 S proteasome (Jakobi et al., 2003). It is not known whether ubiquitination and degradation of PAK-2p34 occurs in the cytoplasm or in the nucleus.
(summation)[Pathway:211733] Regulation of activated PAK-2p34 by proteasome mediated degradation [Homo sapiens]
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