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Details on Person The subcellular localization of PAK-2 is controlled by nucle...
| Class:Id | Summation:211711 |
|---|---|
| _displayName | The subcellular localization of PAK-2 is controlled by nucle... |
| _timestamp | 2008-02-08 00:52:10 |
| created | [InstanceEdit:211710] Matthews, L, 2008-02-08 00:51:52 |
| literatureReference | [LiteratureReference:211655] Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation |
| text | The subcellular localization of PAK-2 is controlled by nuclear localization and nuclear export signal motifs (Jakobi et al.,2003). The regulatory domain contains a nuclear export signal motif that prevents the nuclear accumulation of full-length PAK-2. The activating proteolytic cleavage disrupts the nuclear export signal in PAK-2 and removes most its regulatory domain. The resulting activated PAK-2p34 fragment contains a nuclear localization signal and translocates to and is retained in the nucleus (Jakobi et al.,2003). |
| (summation) | [Reaction:211712] Proteolytic PAK-2p34 fragment translocates to the nucleus [Homo sapiens] [Reaction:266151] Proteolytic PAK-2p34 fragment translocates to the nucleus [Oryctolagus cuniculus] |
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No pathways have been reviewed or authored by The subcellular localization of PAK-2 is controlled by nucle... (211711)
