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Details on Person UniProt:Q6Y5D8 Arhgap10
| Class:Id | ReferenceGeneProduct:211698 |
|---|---|
| _chainChangeLog | chain:1-786 added on Fri February 6 2015 |
| _displayName | UniProt:Q6Y5D8 Arhgap10 |
| _timestamp | 2024-02-26 04:26:41 |
| chain | chain:1-786 |
| checksum | D55F2E694A153D90 |
| comment | FUNCTION GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11238453). Also converts Cdc42 to an inactive GDP-bound state (By similarity). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases (PubMed:11238453). Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (PubMed:15471851). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (By similarity).SUBUNIT Interacts with PKN3 (By similarity). Interacts with caspase-activated PAK2 proteolytic fragment PAK-2p34; the interaction does not affect ARHGAP10 GTPase activation activity towards RHOA and CDC42 (PubMed:15471851). Interacts via its SH3 domain with PTK2/FAK1. Interacts with PTK2B/PYK2; the interaction negatively regulates ARHGAP10 GTPase-activating activity (PubMed:11238453). Interacts with MICAL1 and WDR44; complex formation might transit from GRAF2/ARHGAP10-MICAL1 to GRAF2/ARHGAP10-WDR44 complexes (By similarity).INTERACTION Association to cell membrane is dependent on PH domain. Colocalized with MICAL1, RAB8A, RAB8B and RAB10 on endosomal tubules (By similarity).ALTERNATIVE PRODUCTS High levels of expression in brain, testes, liver, heart and kidney.DOMAIN The BAR domain is important to associate RAB8A (or RAB8B) and RAB10 to endosomal membrane to promote tubule extension. The BAR domain is also important to recruit WDR44 to endosomal tubules.PTM Phosphorylated on tyrosine residues, probably involving PTK2B/PYK2. |
| created | [InstanceEdit:211696] Matthews, L, 2008-02-08 00:48:05 |
| description | recommendedName: Rho GTPase-activating protein 10 alternativeName: PH and SH3 domain-containing rhoGAP protein shortName: PS-GAP shortName: PSGAP alternativeName: Rho-type GTPase-activating protein 10 |
| geneName | Arhgap10 |
| identifier | Q6Y5D8 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Cytoplasm Endosome GTPase activation Membrane Phosphoprotein Reference proteome SH3 domain |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| name | Arhgap10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RHG10_MOUSE Q6Y5D6 Q6Y5D7 Q99MT3 Q99MT4 |
| sequenceLength | 786 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:245545] UniProt:Q6Y5D8-2 Arhgap10 [Mus musculus] [ReferenceIsoform:245546] UniProt:Q6Y5D8-3 Arhgap10 [Mus musculus] [ReferenceIsoform:245547] UniProt:Q6Y5D8-4 Arhgap10 [Mus musculus] [ReferenceIsoform:408849] UniProt:Q6Y5D8-1 Arhgap10 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:211697] PS-GAP [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q6Y5D8 Arhgap10 (211698)
