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Details on Person Autophosphorylation of PAK-2p34 in the activation loop

Class:Id	Reaction:211650
_displayName	Autophosphorylation of PAK-2p34 in the activation loop
_doRelease	TRUE
_timestamp	2008-06-20 12:42:32
authored	[InstanceEdit:211644] Jakobi, R, 2008-02-05 11:04:14
catalystActivity	[CatalystActivity:211667] protein serine/threonine kinase activity of PAK2(213-524) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:211652] Matthews, L, 2008-02-08 00:34:04
edited	[InstanceEdit:211619] Matthews, L, 2008-02-03 20:50:13 [InstanceEdit:351941] Matthews, L, 2008-05-28 22:54:51
inferredFrom	[Reaction:211638] Autophosphorylation of PAK-2p34 [Oryctolagus cuniculus]
input	[EntityWithAccessionedSequence:211653] PAK2(213-524) [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
modified	[InstanceEdit:211760] Matthews, L, 2008-02-08 13:00:24 [InstanceEdit:213014] Matthews, L, 2008-02-19 02:36:57 [InstanceEdit:215255] Matthews, L, 2008-02-27 22:27:17 [InstanceEdit:266359] Gopinathrao, G, 2008-05-06 14:37:06 [InstanceEdit:350634] Matthews, L, 2008-05-20 07:46:51 [InstanceEdit:353176] Matthews, L, 2008-06-12 00:23:53 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of PAK-2p34 in the activation loop
output	[SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:211654] p-T402-PAK2(213-524) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:211651] Cleavage of PAK-2 at 212 [Homo sapiens] [Reaction:211583] Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 [Homo sapiens] [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] [Reaction:114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 [Homo sapiens] [Reaction:418845] Activation of caspase-3 [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:352466] Chang, E, 2008-05-21 00:05:41
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362043] R-HSA-211650.2
summation	[Summation:211624] Activation of PAK-2p34 coincides with autophosphorylation of...
(hasEvent)	[Pathway:211736] Stimulation of the cell death response by PAK-2p34 [Homo sapiens]
(precedingEvent)	[Reaction:211666] Caspase-activated PAK-2 phosphorylates Mnk1 at Ser(27) [Homo sapiens] [Reaction:211712] Proteolytic PAK-2p34 fragment translocates to the nucleus [Homo sapiens] [Reaction:211716] Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34 [Homo sapiens] [BlackBoxEvent:211734] Ubiquitination of PAK-2p34 [Homo sapiens]
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