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Details on Person UniProt:Q29502 PAK2
| Class:Id | ReferenceGeneProduct:211642 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-524 added on Fri February 6 2015;chain:2-212 added on Fri February 6 2015;chain:213-524 added on Fri February 6 2015;initiator methionine:1 for 211642 removed on Fri Nov 03 2023;initiator methionine: for 211642 added on Fri Nov 03 2023;initiator methionine: for 211642 removed on Fri Aug 15 2025;initiator methionine:1 for 211642 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q29502 PAK2 |
| _timestamp | 2025-08-15 22:02:55 |
| chain | initiator methionine:1 chain:2-524 chain:2-212 chain:213-524 |
| checksum | 397D71020EADFFCA |
| comment | FUNCTION Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Phosphorylates CASP7, thereby preventing its activity. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure. Following caspase cleavage, autophosphorylated PAK-2p34 is constitutively active (By similarity).SUBUNIT Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with SCRIB. Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with ARHGAP10. Interacts with RAC1 (By similarity).INTERACTION MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.SUBCELLULAR LOCATION Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.PTM Full-length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate (By similarity).PTM During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34.PTM Ubiquitinated, leading to its proteasomal degradation. |
| created | [InstanceEdit:211639] Matthews, L, 2008-02-08 00:33:15 |
| description | recommendedName: Serine/threonine-protein kinase PAK 2 ecNumber: 2.7.11.1 alternativeName: Gamma-PAK alternativeName: p21-activated kinase 2 shortName: PAK-2 alternativeName: p21-activated protein kinase I shortName: PAKI component recommendedName: PAK-2p27 /component component recommendedName: PAK-2p34 /component |
| geneName | PAK2 |
| identifier | Q29502 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Allosteric enzyme ATP-binding Cytoplasm Kinase Lipoprotein Membrane Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation |
| modified | [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PAK2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PAK2_RABIT |
| sequenceLength | 524 |
| species | [Species:49130] Oryctolagus cuniculus |
| (referenceEntity) | [EntityWithAccessionedSequence:211637] PAK-2p34 [cytosol] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:211641] phospho-PAK-2p34(Thr 402) [cytosol] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:211648] PAK-2 [cytosol] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:211694] PAK-2p34 [nucleoplasm] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:213022] Auto-phosphorylated PAK-2 (p27 regulatory fragment) [cytosol] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:213304] partially auto-phosphorylated PAK-2 (inactive) [cytosol] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:213311] active Pak2 [endoplasmic reticulum membrane] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:266144] phospho-PAK-2p34 (Thr 402) [cytosol] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:266149] phospho-PAK-2p34 (Thr 402) [nucleoplasm] [Oryctolagus cuniculus] [EntityWithAccessionedSequence:3095872] K48polyUb-phospho-PAK-2p34(Thr 402) [cytosol] [Oryctolagus cuniculus] |
| (referenceSequence) | [ModifiedResidue:211640] O-phospho-L-threonine at 402 [ModifiedResidue:213017] O-phospho-L-serine at 197 [ModifiedResidue:213019] O-phospho-L-serine at 19 [ModifiedResidue:213020] O-phospho-L-serine at 192 [ModifiedResidue:213021] O-phospho-L-serine at 55 [ModifiedResidue:213024] O-phospho-L-serine at 20 [ModifiedResidue:213306] O-phospho-L-serine at 141 [GroupModifiedResidue:3095876] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q29502 PAK2 (211642)
