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Details on Person UniProt:P41235-6 HNF4A
| Class:Id | ReferenceIsoform:211473 |
|---|---|
| _chainChangeLog | chain:1-474 added on Fri February 6 2015 |
| _displayName | UniProt:P41235-6 HNF4A |
| _timestamp | 2024-11-03 20:19:26 |
| chain | chain:1-474 |
| checksum | 5F1309B89D95DCAF |
| comment | FUNCTION Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).SUBUNIT Homodimerization is required for HNF4-alpha to bind to its recognition site (PubMed:14982928). Interacts with CLOCK, BMAL1, CRY1, CRY2, PER1 and PER2 (PubMed:30530698). Interacts with NR0B2/SHP; the resulting heterodimer is transcriptionally inactive (PubMed:28128295). Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2 that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (PubMed:28128295).INTERACTION Additional isoforms seem to exist.DOMAIN The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.PTM Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA.PTM Acetylation at Lys-458 lowers transcriptional activation by about two-fold.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Disease susceptibility may be associated with variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Binds fatty acids.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative splicing of isoform HNF4-Alpha-1.MISCELLANEOUS Produced by alternative splicing of isoform HNF4-Alpha-1.MISCELLANEOUS Produced by alternative splicing of isoform HNF4-Alpha-1.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative splicing of isoform HNF4-Alpha-7.MISCELLANEOUS Produced by alternative splicing of isoform HNF4-Alpha-7.SIMILARITY Belongs to the nuclear hormone receptor family. NR2 subfamily.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Hepatocyte nuclear factors entry |
| created | [InstanceEdit:211487] D'Eustachio, P, 2008-02-04 20:56:01 |
| description | recommendedName: Hepatocyte nuclear factor 4-alpha shortName: HNF-4-alpha alternativeName: Nuclear receptor subfamily 2 group A member 1 alternativeName: Transcription factor 14 shortName: TCF-14 alternativeName: Transcription factor HNF-4 |
| geneName | HNF4A HNF4 NR2A1 TCF14 |
| identifier | P41235 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Alternative promoter usage Alternative splicing Biological rhythms Diabetes mellitus Disease variant DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Receptor Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HNF4A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001190] ENSEMBL:ENSG00000101076 HNF4A [Homo sapiens] |
| secondaryIdentifier | HNF4A_HUMAN A5JW41 B2RPP8 O00659 O00723 Q14540 Q5QPB8 Q6B4V5 Q6B4V6 Q6B4V7 Q92653 Q92654 Q92655 Q99864 Q9NQH0 |
| sequenceLength | 474 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P41235-6 |
| (referenceEntity) | [EntityWithAccessionedSequence:211463] HNF4A-6 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P41235-6 HNF4A (211473)
