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Details on Person The GLUT2 gene is transcribed, its mRNA is translated, and t...
| Class:Id | Summation:211471 |
|---|---|
| _displayName | The GLUT2 gene is transcribed, its mRNA is translated, and t... |
| _timestamp | 2008-02-04 20:56:38 |
| created | [InstanceEdit:211487] D'Eustachio, P, 2008-02-04 20:56:01 |
| literatureReference | [LiteratureReference:210828] Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young [LiteratureReference:211459] Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter |
| modified | [InstanceEdit:211491] D'Eustachio, P, 2008-02-04 20:56:48 |
| text | The GLUT2 gene is transcribed, its mRNA is translated, and the protein product is localized to the plasma membrane. GLUT2 expression is positively regulated by HNF1A. In vivo, pancreatic GLUT2 expression is positively regulated by HNF1A. Mutations in HNF1A are associated with a form of MODY (maturity onset diabetes of the young) (Fanjans et al. 2001) and interactions between the HNF1A protein product and the GLUT2 promoter have been demomstrated in vitro (Ban et al. 2002). However, the molecular details of GLUT2 expression in intact pancreatic beta cells have not been studied in humans, but are inferred from corresponding ones worked out in the mouse. |
| (summation) | [BlackBoxEvent:211476] HNF1A-dependent synthesis of GLUT2 protein [Homo sapiens] |
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