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Details on Person UniProt:Q5T0N5-1 FNBP1L
| Class:Id | ReferenceIsoform:211456 |
|---|---|
| _chainChangeLog | chain:1-605 added on Fri February 6 2015 |
| _displayName | UniProt:Q5T0N5-1 FNBP1L |
| _timestamp | 2024-11-03 19:56:10 |
| chain | chain:1-605 |
| checksum | 1D9237185C3006ED |
| comment | FUNCTION Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.SUBUNIT Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures (By similarity). Interacts with GTP-bound CDC42 (PubMed:15260990). Interacts with DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 and WASL/N-WASP (PubMed:16326391, PubMed:16418535, PubMed:16630611). Interacts with ATG3 (PubMed:19342671). Interacts (via SH3 domain) with ABI1, WASF2, CDC42 and WIPF1 (PubMed:19798448).INTERACTION The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).SIMILARITY Belongs to the FNBP1 family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:211455] Gopinathrao, G, 2008-02-04 20:31:34 |
| description | recommendedName: Formin-binding protein 1-like alternativeName: Transducer of Cdc42-dependent actin assembly protein 1 shortName: Toca-1 |
| geneName | FNBP1L C1orf39 TOCA1 |
| identifier | Q5T0N5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Autophagy Cell membrane Coiled coil Cytoplasm Cytoplasmic vesicle Cytoskeleton Endocytosis Lipid-binding Membrane Phosphoprotein Proteomics identification Reference proteome SH3 domain |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FNBP1L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990693] ENSEMBL:ENSG00000137942 FNBP1L [Homo sapiens] |
| secondaryIdentifier | FBP1L_HUMAN J3QSS4 Q5T0N6 Q6B097 Q6P653 Q6R4Q4 Q9NXG1 |
| sequenceLength | 605 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q5T0N5-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:202991] FNBP1L-1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q5T0N5-1 FNBP1L (211456)
