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Details on Person UniProt:Q9UQB8-6 BAIAP2
| Class:Id | ReferenceIsoform:211441 |
|---|---|
| _chainChangeLog | chain:1-552 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UQB8-6 BAIAP2 |
| _timestamp | 2024-11-03 20:18:04 |
| chain | chain:1-552 |
| checksum | 3B9EDC6405DCC99D |
| comment | FUNCTION Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.SUBUNIT Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, ADGRB1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1 (By similarity). Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir.INTERACTION Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.ALTERNATIVE PRODUCTS Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.DOMAIN The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.DOMAIN The SH3 domain interacts with ATN1, ADGRB1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.PTM Phosphorylated on tyrosine residues by INSR in response to insulin treatment.CAUTION It is uncertain whether Met-1 or Met-59 is the initiator. |
| created | [InstanceEdit:211432] Gopinathrao, G, 2008-02-04 20:18:44 |
| description | recommendedName: fullName evidence="24"BAR/IMD domain-containing adapter protein 2 alternativeName: Brain-specific angiogenesis inhibitor 1-associated protein 2 shortName: BAI-associated protein 2 shortName: BAI1-associated protein 2 shortName: Protein BAP2 alternativeName: Fas ligand-associated factor 3 shortName: FLAF3 alternativeName: Insulin receptor substrate p53/p58 shortName: IRS-58 shortName: IRSp53/58 alternativeName: Insulin receptor substrate protein of 53 kDa shortName: IRSp53 shortName: Insulin receptor substrate p53 |
| geneName | BAIAP2 |
| identifier | Q9UQB8 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell projection Coiled coil Cytoplasm Cytoskeleton Membrane Phosphoprotein Proteomics identification Reference proteome SH3 domain |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | BAIAP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991730] ENSEMBL:ENSG00000175866 BAIAP2 [Homo sapiens] |
| secondaryIdentifier | BAIP2_HUMAN O43858 Q53HB1 Q86WC1 Q8N5C0 Q96CR7 Q9UBR3 Q9UQ43 |
| sequenceLength | 552 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9UQB8-6 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UQB8-6 BAIAP2 (211441)
