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Details on Person Cleavage of DFF45 (224) by caspase-3

Class:Id	Reaction:211186
_displayName	Cleavage of DFF45 (224) by caspase-3
_doRelease	TRUE
_timestamp	2008-06-20 09:43:24
authored	[InstanceEdit:211183] Matthews, L, 2008-01-29 12:03:24
catalystActivity	[CatalystActivity:211202] cysteine-type endopeptidase activity of active caspase-3 [nucleoplasm]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:211216] Matthews, L, 2008-01-29 12:04:16
edited	[InstanceEdit:211210] Matthews, L, 2008-01-27 14:01:04 [InstanceEdit:266293] Matthews, L, 2008-05-02 11:33:14
input	[Complex:211208] Caspase cleaved DFFA (117) [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:211226] DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
modified	[InstanceEdit:212529] Matthews, L, 2008-02-12 15:50:30 [InstanceEdit:215500] Gopinathrao, G, 2008-02-29 16:31:42 [InstanceEdit:349497] Matthews, L, 2008-05-08 00:10:16 [InstanceEdit:350337] Matthews, L, 2008-05-18 16:09:48 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of DFF45 (224) by caspase-3
output	[Complex:211196] caspase-3-cleaved DFFA (117,224):DFFB complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:211190] Caspase 3-mediated cleavage of DFF45 (117) [Homo sapiens] [BlackBoxEvent:9029667] DFF dissociates from importin-alpha:importin-beta [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:349495] Widlak, P, 2008-05-07 23:54:18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361033] R-HSA-211186.2
summation	[Summation:211213] Caspase-3 cleaves DFF45 between residues 224,225.
(hasEvent)	[Pathway:140342] Apoptosis induced DNA fragmentation [Homo sapiens]
(precedingEvent)	[Reaction:211207] Cleaved fragments of DFF45 dissociate from DFF40 [Homo sapiens]
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No pathways have been reviewed or authored by Cleavage of DFF45 (224) by caspase-3 (211186)