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Details on Person PECAM-1 becomes tyrosine-phosphorylated during the platelet ...
| Class:Id | Summation:211117 |
|---|---|
| _displayName | PECAM-1 becomes tyrosine-phosphorylated during the platelet ... |
| _timestamp | 2010-06-01 14:53:09 |
| created | [InstanceEdit:211109] Garapati, P V, 2008-01-28 10:30:53 |
| literatureReference | [LiteratureReference:210191] The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling. |
| modified | [InstanceEdit:866439] Jupe, S, 2010-06-01 |
| text | PECAM-1 becomes tyrosine-phosphorylated during the platelet aggregation process; the phosphorylation of two tandem tyrosine residues (Y663 and Y686) within the cytoplasmic domain is required for downstream signalling events. Phosphorylation creates docking sites for the protein-tyrosine phosphatase SHP-2. The interaction between SHP-2 and PECAM-1 is dependent upon integrin-mediated platelet/platelet interactions and occurs via the Src homology 2 (SH2) domains of the phosphatase and highly conserved phosphatase-binding motifs encompassing phosphotyrosines 663 and 686 within the cytoplasmic domain of PECAM-1. |
| (summation) | [Reaction:210294] Interaction of PECAM-1 and SHP-2 [Homo sapiens] |
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No pathways have been reviewed or authored by PECAM-1 becomes tyrosine-phosphorylated during the platelet ... (211117)
