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Details on Person PECAM-1 is capable of transmitting information into the cell...
| Class:Id | Summation:211101 |
|---|---|
| _displayName | PECAM-1 is capable of transmitting information into the cell... |
| _timestamp | 2008-01-28 10:31:16 |
| created | [InstanceEdit:211109] Garapati, P V, 2008-01-28 10:30:53 |
| literatureReference | [LiteratureReference:210123] Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases. [LiteratureReference:211068] Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases |
| text | PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules. |
| (summation) | [Reaction:210291] Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src [Homo sapiens] |
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No pathways have been reviewed or authored by PECAM-1 is capable of transmitting information into the cell... (211101)
