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Details on Person ShcA, an SH2-containing adapter protein, acts as a scaffold ...
| Class:Id | Summation:210994 |
|---|---|
| _displayName | ShcA, an SH2-containing adapter protein, acts as a scaffold ... |
| _timestamp | 2008-02-05 13:52:40 |
| created | [InstanceEdit:210996] Garapati, P V, 2008-01-22 15:12:26 |
| literatureReference | [LiteratureReference:204820] Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells |
| modified | [InstanceEdit:211548] Garapati, P V, 2008-02-05 13:52:09 |
| text | ShcA, an SH2-containing adapter protein, acts as a scaffold for the assembly of signaling proteins involved in the activation of the Ras-MAPK pathway, and potentially other signaling pathways. ShcA is one of the binding partners of endogenous Tie2 receptor on vascular endothelial cells. After Tie2 stimulation by Ang-1 interaction, ShcA associates with Tie2 and becomes tyrosine-phosphorylated. ShcA interacts with the cytoplasmic domain of Tie2 and Y1102 of Tie2 was identified as the primary binding site for the SH2 domain of ShcA. ShcA leads to a reduction of tyrosine phosphorylation of p85 subunit of PI3-kinase and is involved in the inhibition of endothelial cell migration and survival. |
| (summation) | [Reaction:204861] Interaction of Tie2 and Shc1 [Homo sapiens] |
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No pathways have been reviewed or authored by ShcA, an SH2-containing adapter protein, acts as a scaffold ... (210994)
