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Details on Person Interaction of SOS-1 to Tie2 bound Grb2

Class:IdReaction:210974
_displayNameInteraction of SOS-1 to Tie2 bound Grb2
_doReleaseTRUE
_timestamp2009-02-13 12:51:32
authored[InstanceEdit:215562] Garapati, P V, de Bono, B, 2008-03-05 10:26:56
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:210971] Garapati, P V, 2008-01-18 15:29:04
input[Complex:204865] Grb2 bound to Tie2 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:64847] SOS1 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:204811] Tek/Tie2 signaling: new and old partners
[LiteratureReference:204835] GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase
modified[InstanceEdit:210989] Garapati, P V, 2008-01-22 15:06:28
[InstanceEdit:211549] de Bono, B, 2008-02-06 09:45:07
[InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16
[InstanceEdit:214779] Garapati, P V, 2008-02-26 12:15:30
[InstanceEdit:214882] Garapati, P V, 2008-02-26 12:32:59
[InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06
[InstanceEdit:215563] Garapati, P V, 2008-03-05 10:30:39
[InstanceEdit:215569] Garapati, P V, 2008-03-05 12:10:33
[InstanceEdit:391192] Garapati, P V, 2009-02-13 12:51:21
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameInteraction of SOS-1 to Tie2 bound Grb2
output[Complex:210970] SOS-1 bound to Tie2:Grb2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359504] R-HSA-210974.2
summation[Summation:210976] Grb2 binds directly to autophosphorylated Tie2 receptor. GRB...
(hasEvent)[Pathway:210993] Tie2 Signaling [Homo sapiens]
(precedingEvent)[Reaction:210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) [Homo sapiens]
[Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
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