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Details on Person The membrane attack complex (MAC) is the cytolytic end produ...
| Class:Id | Summation:2109539 |
|---|---|
| _displayName | The membrane attack complex (MAC) is the cytolytic end produ... |
| _timestamp | 2016-01-20 15:09:41 |
| created | [InstanceEdit:2109534] Jupe, S, 2012-02-13 |
| literatureReference | [LiteratureReference:2109533] Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly [LiteratureReference:8852752] Structure of complement poly-C9 determined in projection by cryo-electron microscopy and single particle analysis |
| modified | [InstanceEdit:2109564] Jupe, S, 2012-02-13 [InstanceEdit:8852733] Jupe, Steve, 2016-01-20 |
| text | The membrane attack complex (MAC) is the cytolytic end product of the complement cascade, composed of one C5:C6:C7:C8 complex and 12 to 15 C9 molecules (Podack et al. 1982, Biesecker et al. 1993). 12 C9 molecules are represented in this reaction. C9 peptides polymerize to form a ring-shaped transmembrane channel, which causes osmotic lysis of the target cell (Kondos et al. 2010). While formation of a pore is typically associated with necrotic cell death, there is evidence of membrane permeabilization from MACs containing one C9 molecule per C5b–8 complex (Sims et al. 1983). |
| (summation) | [Reaction:173725] C9 binds C5b:C6:C7:C8 [Homo sapiens] |
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