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Details on Person The HES1 gene is transcribed, its mRNA is translated, and th...
| Class:Id | Summation:210830 |
|---|---|
| _displayName | The HES1 gene is transcribed, its mRNA is translated, and th... |
| _timestamp | 2008-01-17 00:37:25 |
| created | [InstanceEdit:210826] D'Eustachio, P, 2008-01-17 00:37:13 |
| literatureReference | [LiteratureReference:210831] Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription |
| text | The HES1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus during morphogenesis of the pancreas. HES1 transcription requires the activity of the RBPJ transcription factor and the NOTCH1 intracellular domain, probably as a complex (Aster et al. 1997). These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse. |
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No pathways have been reviewed or authored by The HES1 gene is transcribed, its mRNA is translated, and th... (210830)
