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Details on Person WWTR1:SMAD stimulates transcription of SMAD7

Class:IdBlackBoxEvent:2106591
_displayNameWWTR1:SMAD stimulates transcription of SMAD7
_doReleaseTRUE
_timestamp2022-05-09 21:49:30
authored[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:2106589] Orlic-Milacic, M, 2012-02-10
edited[InstanceEdit:2187413] Jassal, B, 2012-04-10
[InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
input[EntityWithAccessionedSequence:2106587] SMAD7 gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2031354] TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
[LiteratureReference:5251997] Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals
modified[InstanceEdit:2106595] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2187535] Orlic-Milacic, M, 2012-04-10
[InstanceEdit:2197659] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2250388] Orlic-Milacic, M, 2012-05-15
[InstanceEdit:5671931] Jassal, Bijay, 2015-02-03
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9645251] Jassal, Bijay, 2019-05-07
[InstanceEdit:9736976] Orlic-Milacic, Marija, 2021-07-15
[InstanceEdit:9754418] Orlic-Milacic, Marija, 2021-09-24
[InstanceEdit:9773749] Orlic-Milacic, Marija, 2022-05-09
[InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameWWTR1:SMAD stimulates transcription of SMAD7
output[EntityWithAccessionedSequence:178197] SMAD7 [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[PositiveGeneExpressionRegulation:2106584] Positive gene expression regulation by 'WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:5255397] Positive gene expression regulation by 'ATP1B4:SNW1 [nucleoplasm]'
regulationReference[RegulationReference:9642308] Positive gene expression regulation by 'WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm]' TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
releaseDate2012-06-12
reviewed[InstanceEdit:2250308] Huang, Tao, 2012-05-14
[InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294703] R-HSA-2106591.7
summation[Summation:2106596] Knocking down WWTR1 (TAZ) expression by siRNA treatment inhi...
(hasEvent)[Pathway:2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity [Homo sapiens]
(precedingEvent)[Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) [Homo sapiens]
[Reaction:178208] SMAD7 binds to SMURF2 [Homo sapiens]
[Reaction:2167917] SMAD7 binds to SMURF1 [Homo sapiens]
[Reaction:2176416] NEDD4L ubiquitin ligase binds SMAD7 [Homo sapiens]
[Reaction:2186771] RNF111 binds SMAD7 [Homo sapiens]
[Reaction:9736966] SMAD7 binds SERPINE1 gene promoter [Homo sapiens]
[Reaction:9846236] GOCAM I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) [Homo sapiens]
[Reaction:9846238] GOCAM NEDD4L ubiquitin ligase binds SMAD7 [Homo sapiens]
[Reaction:9846247] GOCAM SMAD7 binds to SMURF2 [Homo sapiens]
[Reaction:9846252] GOCAM SMAD7 binds to SMURF1 [Homo sapiens]
List all 11 refering instances
(updatedInstance)[_UpdateTracker:9775746] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v78:[add_removeRegulator]
[_UpdateTracker:9785313] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v52:[addLiteratureReference, addRegulator, modifyText]
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No pathways have been reviewed or authored by WWTR1:SMAD stimulates transcription of SMAD7 (2106591)
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