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Details on Person JAK2 [cytosol]
Class:Id EntityWithAccessionedSequence:210620
_displayName JAK2 [cytosol]
_timestamp 2016-11-29 15:48:14
compartment [Compartment:70101] cytosol
created [InstanceEdit:210618] Williams, MG, 2008-01-15 15:30:58
endCoordinate 1132
modified [InstanceEdit:3132750] Wu, G, 2013-02-13 [InstanceEdit:8949827] Jupe, Steve, 2016-11-29
name JAK2 Tyrosine-protein kinase JAK2
referenceEntity [ReferenceGeneProduct:57647] UniProt:O60674 JAK2 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:1107148] R-HSA-210620.2
startCoordinate 1
(activeUnit) [CatalystActivity:873920] protein tyrosine kinase activity of IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] [CatalystActivity:914083] non-membrane spanning protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] [CatalystActivity:2447206] protein tyrosine kinase activity of JAK2:SFKS:p-KIT complex [plasma membrane] [CatalystActivity:2586550] protein tyrosine kinase activity of LEP:LEPR:JAK2 [plasma membrane] [CatalystActivity:9006324] protein tyrosine kinase activity of EPO:EPOR:JAK2:LYN:IRS2 [plasma membrane] [CatalystActivity:9670409] protein tyrosine kinase activity of KIT mutant dimers:SFKs:JAK2 [plasma membrane]
(hasCandidate) [CandidateSet:5672734] RAF activating kinases [plasma membrane] [Homo sapiens] [CandidateSet:8987151] JAK2, JAK3 [cytosol] [Homo sapiens]
(hasComponent) [Complex:873808] IFNGR2:JAK2 [plasma membrane] [Homo sapiens] [Complex:879945] IL3RB:JAK2 [plasma membrane] [Homo sapiens] [Complex:912316] pY593,Y628-IL3RB:JAK2 [plasma membrane] [Homo sapiens] [Complex:914033] p(Y593)-Bc:JAK2 [plasma membrane] [Homo sapiens] [Complex:914173] p-S585-IL3RB:JAK2 [plasma membrane] [Homo sapiens] [Complex:982774] Growth Hormone Receptor:JAK2 [plasma membrane] [Homo sapiens] [Complex:1168397] Activated Growth Hormone Receptor:JAK2 [plasma membrane] [Homo sapiens] [Complex:1169223] Tyrosine phosphorylated Growth Hormone Receptor:JAK2 [plasma membrane] [Homo sapiens] [Complex:1302663] PRLR:JAK2 [plasma membrane] [Homo sapiens] [Complex:1370506] p(S349)-PRLR:JAK2 [plasma membrane] [Homo sapiens]
(hasMember) [CandidateSet:1067656] JAK1, JAK2, (TYK2) [cytosol] [Homo sapiens]
(input) [Reaction:879937] The common beta chain IL3RB binds JAK2 [Homo sapiens] [Reaction:982792] Growth hormone receptor binds JAK2 [Homo sapiens] [Reaction:1302698] PRLR associates with JAK2 [Homo sapiens] [Reaction:1433451] JAK2 binds to p-KIT [Homo sapiens] [Reaction:6785898] IL4R binds JAK2 [Homo sapiens] [Reaction:8950063] IL12RB2 binds JAK2 [Homo sapiens] [Reaction:8950737] IL23R binds JAK2 [Homo sapiens] [Reaction:9670413] JAK2 binds to p-KIT mutants [Homo sapiens] [BlackBoxEvent:9676071] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK [Homo sapiens]
(output) [Reaction:210691] Phosphorylated JAK2 is dephosphorylated by PTP1B [Homo sapiens]
(updatedInstance) [_UpdateTracker:9876052] Update Tracker - [EntityWithAccessionedSequence:210620] JAK2 [cytosol] - v44:[modifyEndCoordinate] [_UpdateTracker:9895842] Update Tracker - [EntityWithAccessionedSequence:210620] JAK2 [cytosol] - v60:[addName]
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Pathways
No pathways have been reviewed or authored by JAK2 [cytosol] (210620)