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Details on Person L-Glutamate loading of synaptic vesicle

Class:Id	Reaction:210444
_displayName	L-Glutamate loading of synaptic vesicle
_doRelease	TRUE
_timestamp	2016-11-10 00:55:07
authored	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
catalystActivity	[CatalystActivity:210513] L-glutamate transmembrane transporter activity of Empty Glutamate Synaptic Vesicle [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
edited	[InstanceEdit:447013] Gillespie, ME, 2009-11-19
input	[SimpleEntity:29404] L-Glu [cytosol] [Complex:264795] Empty Glutamate Synaptic Vesicle [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:210506] Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons [LiteratureReference:349532] Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
modified	[InstanceEdit:210543] Mahajan, SS, 2008-01-14 16:06:22 [InstanceEdit:212600] Mahajan, SS, 2008-02-12 19:05:29 [InstanceEdit:264789] Gillespie, ME, 2008-04-07 13:55:58 [InstanceEdit:264797] Mahajan, SS, 2008-04-07 14:36:02 [InstanceEdit:264814] Mahajan, SS, 2008-04-07 14:52:12 [InstanceEdit:349566] Mahajan, SS, 2008-05-09 15:28:28 [InstanceEdit:350548] Mahajan, SS, 2008-05-19 15:52:58 [InstanceEdit:354052] Gopinathrao, G, 2008-06-16 15:49:02 [InstanceEdit:374942] Mahajan, SS, 2008-08-05 20:37:09 [InstanceEdit:379352] Mahajan, SS, 2008-10-16 19:28:29 [InstanceEdit:447304] Mahajan, SS, 2009-11-21 [InstanceEdit:513018] D'Eustachio, P, 2010-02-16 [InstanceEdit:513021] D'Eustachio, P, 2010-02-16 [InstanceEdit:633892] Mahajan, SS, 2010-04-29 [InstanceEdit:660242] D'Eustachio, P, 2010-04-30 [InstanceEdit:3150161] D'Eustachio, P, 2013-02-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	L-Glutamate loading of synaptic vesicle
output	[Complex:210380] Glutamate loaded synaptic vesicle [cytosol] [Homo sapiens]
precedingEvent	[Reaction:210404] SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ [Homo sapiens] [Reaction:210430] Release of L-Glutamate at the synapse [Homo sapiens] [BlackBoxEvent:379324] Re-acidification of glutamate transport vesicle [Homo sapiens] [Reaction:70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] [Homo sapiens] [Reaction:70609] glutamine + H2O => glutamate + NH4+ (GLS) [Homo sapiens] [BlackBoxEvent:212651] Transport of L-Glutamine (cytosol) to mitochondrial matrix [Homo sapiens] [Reaction:212614] Glutamine transport from astrocytes [Homo sapiens] [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:349531] Kavalali, E, 2008-04-24 16:31:34
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360067] R-HSA-210444.3
summation	[Summation:210429] Nascent synaptic vesicles are loaded with glutamate by VGLUT...
(hasEvent)	[Pathway:210500] Glutamate Neurotransmitter Release Cycle [Homo sapiens]
(precedingEvent)	[Reaction:210426] Glutamate synaptic vesicle docking and priming [Homo sapiens] [Reaction:372505] Acetylcholine synaptic vesicle docking and priming [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791826] Update Tracker - [Reaction:210444] L-Glutamate loading of synaptic vesicle - v25:[addLiteratureReference, add_removeInput]
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