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Details on Person UniProt:O14810 CPLX1
| Class:Id | ReferenceGeneProduct:210434 |
|---|---|
| _chainChangeLog | chain:1-134 added on Fri February 6 2015 |
| _displayName | UniProt:O14810 CPLX1 |
| _timestamp | 2024-11-03 19:50:34 |
| chain | chain:1-134 |
| checksum | A7A52F17F10D28A4 |
| comment | FUNCTION Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.SUBUNIT Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.INTERACTION Enriched at synaptic-releasing sites in mature neurons.TISSUE SPECIFICITY Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complexin/synaphin family. |
| created | [InstanceEdit:210485] 2008-01-14 10:59:03 |
| description | recommendedName: Complexin-1 alternativeName: Complexin I shortName: CPX I alternativeName: Synaphin-2 |
| geneName | CPLX1 |
| identifier | O14810 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell projection Coiled coil Cytoplasm Disease variant Epilepsy Exocytosis Neurotransmitter transport Proteomics identification Reference proteome Synapse Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CPLX1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987755] ENSEMBL:ENSG00000168993 CPLX1 [Homo sapiens] |
| secondaryIdentifier | CPLX1_HUMAN A6NI80 B2R4R5 D3DVN3 F1T0G1 |
| sequenceLength | 134 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:210385] CPLX1 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O14810 CPLX1 (210434)
