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Details on Person SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+

Class:Id	Reaction:210404
_displayName	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+
_doRelease	TRUE
_timestamp	2019-12-17 16:40:58
authored	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
catalystActivity	[CatalystActivity:428035] high-affinity L-glutamate transmembrane transporter activity of SLC1A1-3,6,7 [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:210543] Mahajan, SS, 2008-01-14 16:06:22
edited	[InstanceEdit:447013] Gillespie, ME, 2009-11-19
input	[SimpleEntity:210382] L-Glu [extracellular region] [SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:29804] K+ [cytosol]
literatureReference	[LiteratureReference:5625016] Glutamate as a neurotransmitter in the healthy brain [LiteratureReference:427990] Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures [LiteratureReference:5250235] Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18
modified	[InstanceEdit:210544] Mahajan, SS, 2008-01-14 16:17:51 [InstanceEdit:212600] Mahajan, SS, 2008-02-12 19:05:29 [InstanceEdit:264814] Mahajan, SS, 2008-04-07 14:52:12 [InstanceEdit:349566] Mahajan, SS, 2008-05-09 15:28:28 [InstanceEdit:350548] Mahajan, SS, 2008-05-19 15:52:58 [InstanceEdit:374942] Mahajan, SS, 2008-08-05 20:37:09 [InstanceEdit:377487] D'Eustachio, P, 2008-09-12 21:45:58 [InstanceEdit:447303] Mahajan, SS, 2009-11-21 [InstanceEdit:3150161] D'Eustachio, P, 2013-02-19 [InstanceEdit:5671864] Jassal, Bijay, 2015-02-03 [InstanceEdit:5674209] Jassal, Bijay, 2015-02-11 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9632232] Jassal, Bijay, 2018-12-17 [InstanceEdit:9670982] Jassal, Bijay, 2019-12-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ L-Glutamate uptake by neurons
output	[SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:74126] K+ [extracellular region] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol]
precedingEvent	[Reaction:210430] Release of L-Glutamate at the synapse [Homo sapiens] [Reaction:210426] Glutamate synaptic vesicle docking and priming [Homo sapiens] [Reaction:210420] Ca2+ influx through voltage gated Ca2+ channels [Homo sapiens] [Reaction:9670745] LTCC pentamer transports Ca2+ from extracellular region to cytosol in neurons [Homo sapiens]
regulatedBy	[NegativeRegulation:5671866] Negative regulation by 'ARL6IP5 [cytosol]'
releaseDate	2008-06-30
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359909] R-HSA-210404.5
summation	[Summation:212637] There are two classes of glutamate transporters; the excitat...
(hasEvent)	[Pathway:210500] Glutamate Neurotransmitter Release Cycle [Homo sapiens]
(precedingEvent)	[Reaction:210444] L-Glutamate loading of synaptic vesicle [Homo sapiens]
(replacementInstances)	[_Deleted:9971768] Deletion of instance: 5250230
(updatedInstance)	[_UpdateTracker:9778575] Update Tracker - [Reaction:210404] SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ - v68:[add_removeCatalystActivity] [_UpdateTracker:9784897] Update Tracker - [Reaction:210404] SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ - v52:[addInput, addOutput, addRegulator, add_removeLiteratureReference, modifyText]
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No pathways have been reviewed or authored by SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (210404)