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Details on Person Interaction of PECAM-1 and SHP-2

Class:Id	Reaction:210294
_displayName	Interaction of PECAM-1 and SHP-2
_doRelease	TRUE
_timestamp	2009-10-29 14:55:38
authored	[InstanceEdit:214881] de Bono, B, Garapati, P V, 2008-02-26 12:30:30
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:210296] Garapati, P V, 2008-01-10 13:46:10
input	[EntityWithAccessionedSequence:210007] p-Y663,Y686-PECAM1(27-?) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:210191] The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling.
modified	[InstanceEdit:211109] Garapati, P V, 2008-01-28 10:30:53 [InstanceEdit:211549] de Bono, B, 2008-02-06 09:45:07 [InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16 [InstanceEdit:214779] Garapati, P V, 2008-02-26 12:15:30 [InstanceEdit:214882] Garapati, P V, 2008-02-26 12:32:59 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:445349] Jupe, S, 2009-10-29 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Interaction of PECAM-1 and SHP-2
output	[Complex:210219] PECAM-1:SHP-2 complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:210291] Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src [Homo sapiens] [BlackBoxEvent:435244] PECAM1 is phosphorylated [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359081] R-HSA-210294.2
summation	[Summation:211117] PECAM-1 becomes tyrosine-phosphorylated during the platelet ...
(hasEvent)	[Pathway:210990] PECAM1 interactions [Homo sapiens] [Pathway:432142] Platelet sensitization by LDL [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790750] Update Tracker - [Reaction:210294] Interaction of PECAM-1 and SHP-2 - v33:[modifyText]
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No pathways have been reviewed or authored by Interaction of PECAM-1 and SHP-2 (210294)