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Details on Person The first and rate limiting step in serotonin (5-HT) biosynt...
| Class:Id | Summation:209975 |
|---|---|
| _displayName | The first and rate limiting step in serotonin (5-HT) biosynt... |
| _timestamp | 2010-10-12 11:59:36 |
| created | [InstanceEdit:209970] Jassal, Bijay, 2008-01-08 |
| literatureReference | [LiteratureReference:209787] Tetrahydropterin-dependent amino acid hydroxylases |
| modified | [InstanceEdit:976254] Jassal, B, 2010-10-12 |
| text | The first and rate limiting step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase. The enzyme requires iron(II), tetrahydrobiopterin, and dioxygen cofactors for the hydroxylation of L-tryptophan to 5-hydroxytryptophan. Tryptophan hydroxylase belongs to a small family of monooxygenases that utilize tetrahydrobiopterins. Other members are phenylalanine hydroxylase and tyrosine hydroxylase (Fitzpatrick, PF, 1999; Walther et al, 2003). |
| (summation) | [Reaction:209828] Tryptophan is hydroxylated [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The first and rate limiting step in serotonin (5-HT) biosynt... (209975)
