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Details on Person CYP2R1 25-hydroxylates VD3 to 25(OH)D

Class:IdReaction:209845
_displayNameCYP2R1 25-hydroxylates VD3 to 25(OH)D
_doReleaseTRUE
_timestamp2017-11-09 17:09:35
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:209900] vitamin D3 25-hydroxylase activity of CYP2R1 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:209970] Jassal, Bijay, 2008-01-08
edited[InstanceEdit:351780] Jassal, B, 2008-05-28 09:06:10
[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
input[SimpleEntity:8963870] VD3 [endoplasmic reticulum membrane]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
literatureReference[LiteratureReference:209913] Metabolism of vitamin D by human microsomal CYP2R1
[LiteratureReference:8963867] De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase
modified[InstanceEdit:215585] Jassal, B, 2008-03-06 14:26:56
[InstanceEdit:350121] Jassal, Bijay, 2008-05-14
[InstanceEdit:350226] Jassal, B, 2008-05-15 08:18:31
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:350840] Jassal, B, 2008-05-21 10:32:15
[InstanceEdit:351780] Jassal, B, 2008-05-28 09:06:10
[InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30
[InstanceEdit:352333] Jassal, B, 2008-06-02 13:27:43
[InstanceEdit:352338] Jassal, B, 2008-06-02 16:22:02
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:8963878] Jassal, Bijay, 2017-02-13
[InstanceEdit:8963880] Jassal, Bijay, 2017-02-13
[InstanceEdit:9028764] Jassal, Bijay, 2017-11-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCYP2R1 25-hydroxylates VD3 to 25(OH)D
output[SimpleEntity:8963879] 25(OH)D [endoplasmic reticulum membrane]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
precedingEvent
releaseDate2008-06-30
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358770] R-HSA-209845.4
summation[Summation:215578] To be functionally active, vitamin D3 (VD3) needs to be dihy...
(hasEvent)[Pathway:196791] Vitamin D (calciferol) metabolism [Homo sapiens]
[Pathway:209896] Vitamin D3 biosynthesis [Homo sapiens]
[Pathway:211916] Vitamins [Homo sapiens]
(normalReaction)[FailedReaction:5602147] Defective CYP2R1 does not 25-hydroxylate vitamin D [Homo sapiens]
(precedingEvent)[Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D [Homo sapiens]
[BlackBoxEvent:6807242] 25(OH)D translocates from ER membrane to extracellular region [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780327] Update Tracker - [Reaction:209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - v63:[modifyText]
[_UpdateTracker:9781596] Update Tracker - [Reaction:209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - v60:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9786249] Update Tracker - [Reaction:209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - v50:[modifyText]
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