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Details on Person Tryptophan is hydroxylated

Class:IdReaction:209828
_displayNameTryptophan is hydroxylated
_doReleaseTRUE
_timestamp2010-10-12 11:59:53
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:209966] tryptophan 5-monooxygenase activity of TPH:Fe++ [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:209970] Jassal, Bijay, 2008-01-08
edited[InstanceEdit:209970] Jassal, Bijay, 2008-01-08
input[SimpleEntity:29500] L-Trp [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:29870] BH4 [cytosol]
literatureReference[LiteratureReference:209854] Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin
[LiteratureReference:976258] Synthesis of serotonin by a second tryptophan hydroxylase isoform
modified[InstanceEdit:352276] Jassal, Bijay, 2008-06-02
[InstanceEdit:352325] Jassal, Bijay, 2008-06-02
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:386926] Mahajan, SS, 2008-11-27 13:14:44
[InstanceEdit:976254] Jassal, B, 2010-10-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTryptophan is hydroxylated
output[SimpleEntity:209911] 5HTP [cytosol]
[SimpleEntity:71112] 4aOH-BH4 [cytosol]
releaseDate2008-06-30
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:387615] R-HSA-209828.2
summation[Summation:209975] The first and rate limiting step in serotonin (5-HT) biosynt...
(hasEvent)[Pathway:209931] Serotonin and melatonin biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:209859] Decarboxylation of 5-hydroxytryptophan forms serotonin [Homo sapiens]
(replacementInstances)[_Deleted:660237] Deletion of instance: 379379
(updatedInstance)[_UpdateTracker:9790124] Update Tracker - [Reaction:209828] Tryptophan is hydroxylated - v35:[addLiteratureReference, modifyText]
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