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Details on Person CYP24A1 hydroxylates 1,25(OH)2D, inactivating it

Class:Id	Reaction:209765
_displayName	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
_doRelease	TRUE
_timestamp	2020-07-03 14:25:21
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:215644] 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity of CYP24A1 [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:70101] cytosol
created	[InstanceEdit:209769] Jassal, B, 2008-01-07 09:34:20
edited	[InstanceEdit:352314] Jassal, B, 2008-06-02 10:50:11
input	[SimpleEntity:209800] 1,25(OH)2D [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:350175] Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA [LiteratureReference:215581] Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme [LiteratureReference:215627] Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24
modified	[InstanceEdit:350121] Jassal, Bijay, 2008-05-14 [InstanceEdit:352325] Jassal, Bijay, 2008-06-02 [InstanceEdit:352338] Jassal, B, 2008-06-02 16:22:02 [InstanceEdit:353620] Jassal, B, 2008-06-13 09:28:46 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8963878] Jassal, Bijay, 2017-02-13 [InstanceEdit:8979066] Jassal, Bijay, 2017-02-21 [InstanceEdit:9028764] Jassal, Bijay, 2017-11-09 [InstanceEdit:9693635] Jassal, Bijay, 2020-07-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
output	[SimpleEntity:350159] CTA [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D [Homo sapiens] [BlackBoxEvent:209766] 25(OH)D translocates from lysosomal lumen to cytosol [Homo sapiens] [Reaction:209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D [Homo sapiens]
regulatedBy	[PositiveRegulation:9692886] Positive regulation by 'Fru [cytosol]'
releaseDate	2008-06-30
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360719] R-HSA-209765.5
summation	[Summation:350089] 1-alpha, 25-dihydroxyvitamin D (1,25(OH)2D) is biologically ...
(hasEvent)	[Pathway:196791] Vitamin D (calciferol) metabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776747] Update Tracker - [Reaction:209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - v74:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9780351] Update Tracker - [Reaction:209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - v63:[modifyText] [_UpdateTracker:9780711] Update Tracker - [Reaction:209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - v62:[modifyText]
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