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Details on Person Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen

Class:Id	BlackBoxEvent:209760
_displayName	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen
_doRelease	TRUE
_timestamp	2025-07-03 21:44:29
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
compartment	[Compartment:70101] cytosol [Compartment:161320] lysosomal lumen
created	[InstanceEdit:209769] Jassal, B, 2008-01-07 09:34:20
edited	[InstanceEdit:352314] Jassal, B, 2008-06-02 10:50:11
goBiologicalProcess	[GO_BiologicalProcess:258911] intracellular lipid transport
input	[Complex:350092] CUBN:GC:25(OH)D [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:350138] Autocatalytic activation of human legumain at aspartic acid residues [LiteratureReference:350091] Activation of human prolegumain by cleavage at a C-terminal asparagine residue
modified	[InstanceEdit:350121] Jassal, Bijay, 2008-05-14 [InstanceEdit:352338] Jassal, B, 2008-06-02 16:22:02 [InstanceEdit:352342] Jassal, B, 2008-06-02 16:28:42 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:6807513] D'Eustachio, Peter, 2015-11-02 [InstanceEdit:8963878] Jassal, Bijay, 2017-02-13 [InstanceEdit:9028764] Jassal, Bijay, 2017-11-09 [InstanceEdit:9639412] D'Eustachio, Peter, 2019-03-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9959973] D'Eustachio, Peter, 2025-07-03
name	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen
output	[Complex:350085] CUBN:GC:25(OH)D [lysosomal lumen] [Homo sapiens]
precedingEvent	[Reaction:350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D [Homo sapiens] [Reaction:350186] CUBN binds GC:25(OH)D [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359392] R-HSA-209760.7
summation	[Summation:350145] The internalized CUBN:GC:25(OH)D complex enters the lysosome...
(hasEvent)	[Pathway:196791] Vitamin D (calciferol) metabolism [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:350158] LGMN hydrolyzes GC, releasing CUBN and 25(OH)D [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780204] Update Tracker - [BlackBoxEvent:209760] Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen - v63:[modifyText] [_UpdateTracker:9780743] Update Tracker - [BlackBoxEvent:209760] Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen - v62:[modifyText]
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No pathways have been reviewed or authored by Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (209760)