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Details on Person Monomeric PGN binds to PGRP-LCx at the plasma membrane

Class:Id	Reaction:209355
_displayName	Monomeric PGN binds to PGRP-LCx at the plasma membrane
_doRelease	TRUE
_timestamp	2018-03-09 00:15:03
authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:358144] /figures/DrosTollImdC26.jpg
input	[SimpleEntity:205686] Mono PGN [extracellular region] [EntityWithAccessionedSequence:205794] PGRP-LCx [plasma membrane] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208221] PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan [LiteratureReference:208268] Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor [LiteratureReference:208365] Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro [LiteratureReference:208071] Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition [LiteratureReference:208161] Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins [LiteratureReference:208121] Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway
modified	[InstanceEdit:214886] Williams, MG, 2008-02-26 12:31:57 [InstanceEdit:358146] Williams, MG, 2008-06-19 09:32:34 [InstanceEdit:372363] Williams, MG, 2008-06-23 10:13:54 [InstanceEdit:386960] Williams, MG, 2008-11-27 15:03:15 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Monomeric PGN binds to PGRP-LCx at the plasma membrane
output	[Complex:206681] Mono PGN:PGRP-LCx [plasma membrane] [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8931281] R-DME-209355.4
summation	[Summation:206428] Peptidoglycan recognition protein, PGRP-LCa receptor shows o...
(hasEvent)	[Pathway:209171] Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE [Drosophila melanogaster]
(precedingEvent)	[Reaction:209185] Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane [Drosophila melanogaster]
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