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Details on Person Human PKA phosphorylates RAF1 in the vicinity of its C1 domain

Class:Id	Reaction:209343
_displayName	Human PKA phosphorylates RAF1 in the vicinity of its C1 domain
_doRelease	FALSE
_timestamp	2016-07-15 23:48:56
authored	[InstanceEdit:386944] Williams, MG, 2007-10-26 16:49:12
catalystActivity	[CatalystActivity:208916] protein serine/threonine kinase activity of PKA catalytic subunit [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205618] Williams, MG, 2007-10-30 11:44:05
figure	[Figure:947886] /figures/DrosRasRafERKA25.jpg
input	[EntityWithAccessionedSequence:167205] RAF1 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:208050] Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259 [LiteratureReference:208143] Negative regulation of Raf-1 by phosphorylation of serine 621
modified	[InstanceEdit:209256] Williams, MG, 2007-10-30 11:57:39 [InstanceEdit:350503] Williams, MG, 2008-05-19 14:17:19 [InstanceEdit:386959] Williams, MG, 2008-11-27 14:56:57 [InstanceEdit:947989] Williams, MG, 2010-09-14 [InstanceEdit:948073] Williams, MG, 2010-09-16 [InstanceEdit:3009422] Jassal, B, 2013-02-05 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Human PKA phosphorylates RAF1 in the vicinity of its C1 domain
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:109786] p-S259,S621-RAF1 [cytosol] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8880391] R-HSA-209343.1
summation	[Summation:948059] In humans, PKA kinase phosphorylates Ser259 and Ser621 in RA...
(hasEvent)	[Pathway:481001] Ras/Raf/ERK pathway - Inferred Events
(inferredFrom)	[Reaction:209270] PKA-C1 phosphorylates PHL in the vicinity of its C1 domain [Drosophila melanogaster]
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No pathways have been reviewed or authored by Human PKA phosphorylates RAF1 in the vicinity of its C1 domain (209343)