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Details on Person Phosphorylation of SMO by PKA-C1

Class:Id	Reaction:209341
_displayName	Phosphorylation of SMO by PKA-C1
_doRelease	TRUE
_timestamp	2018-03-09 00:17:39
authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
catalystActivity	[CatalystActivity:208927] protein serine/threonine kinase activity of CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205626] Williams, MG, 2006-12-08 11:30:45
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:216285] /figures/DrosHHB17.jpg
input	[Complex:216146] SMO:COS:CI:FU [plasma membrane] [Drosophila melanogaster] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:208360] Extensive phosphorylation of Smoothened in Hedgehog pathway activation [LiteratureReference:208065] Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I [LiteratureReference:208388] Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
modified	[InstanceEdit:216199] Williams, MG, 2008-03-11 15:41:17 [InstanceEdit:350536] Williams, MG, 2008-05-19 14:40:19 [InstanceEdit:386962] Williams, MG, 2008-11-27 15:15:51 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of SMO by PKA-C1
output	[Complex:216105] Phospho (3 sites) SMO:COS:CI:FU [plasma membrane] [Drosophila melanogaster] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:209178] N-HH binds to PTC receptor complex [Drosophila melanogaster] [Reaction:209272] N-HH binds to the transmembrane HSPG proteins [Drosophila melanogaster] [Reaction:216222] COS binds to SMO [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8922967] R-DME-209341.4
summation	[Summation:206467] The Ser/Thr kinase, Protein kinase A (PKA-C1) carries out pr...
(hasEvent)	[Pathway:209214] Phosphorylation of SMO [Drosophila melanogaster]
(precedingEvent)	[Reaction:209168] Phosphorylation of SMO by CKIalpha [Drosophila melanogaster]
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No pathways have been reviewed or authored by Phosphorylation of SMO by PKA-C1 (209341)