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Details on Person SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription

Class:Id	Reaction:209296
_displayName	SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription
_doRelease	TRUE
_timestamp	2017-08-10 21:58:18
authored	[InstanceEdit:386954] Williams, MG, 2006-11-02 16:49:12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:205673] Williams, MG, 2006-11-03 15:40:44
edited	[InstanceEdit:205673] Williams, MG, 2006-11-03 15:40:44
figure	[Figure:208431] /figures/ADrosJAKSTAT11.jpg
input	[EntityWithAccessionedSequence:205759] SU(VAR)2-10 [nucleoplasm] [Drosophila melanogaster] [Complex:207031] Phospho STAT92E dimer [nucleoplasm] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208056] A Drosophila PIAS homologue negatively regulates stat92E [LiteratureReference:208342] The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family [LiteratureReference:208336] Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction [LiteratureReference:208136] Specific inhibition of Stat3 signal transduction by PIAS3
modified	[InstanceEdit:210701] Williams, MG, 2008-01-15 15:35:58 [InstanceEdit:350538] Williams, MG, 2008-05-19 14:41:26 [InstanceEdit:386963] Williams, MG, 2008-11-27 15:33:38 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9015677] D'Eustachio, Peter, 2017-08-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription
output	[Complex:206936] SU(VAR)2-10:Phospho STAT92E:Phospho STAT92E [nucleoplasm] [Drosophila melanogaster]
precedingEvent	[Reaction:209365] Phosphorylated STAT92E dimer transports from the cytosol to the nucleus [Drosophila melanogaster] [Reaction:209321] Phosphorylated STAT92E dissociates from HOP and DOME and dimerises [Drosophila melanogaster]
releaseDate	2009-03-12
reviewed	[InstanceEdit:386947] Perrimon, N, 2008-01-16 11:04:04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8898691] R-DME-209296.2
summation	[Summation:206456] The negative pathway regulator SU(VAR)2-10 physically intera...
(hasEvent)	[Pathway:210671] Transcriptional repression by nuclear factors [Drosophila melanogaster]
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No pathways have been reviewed or authored by SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription (209296)