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Details on Person KUZ cleaves N at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD

Class:Id	Reaction:209287
_displayName	KUZ cleaves N at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD
_doRelease	FALSE
_timestamp	2016-07-15 23:49:52
authored	[InstanceEdit:386943] Williams, MG, 2006-09-21 16:49:12
catalystActivity	[CatalystActivity:208862] metalloendopeptidase activity of KUZ [plasma membrane]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:205681] Williams, MG, 2006-09-21 15:05:28
figure	[Figure:208702] /figures/DrosNotch08A.jpg
inferredFrom	[Reaction:209162] Murine ADAM10 cleaves Notch at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD [Mus musculus]
input	[Complex:206599] KUZ:Fucosylated N:UBI-P63E:DL/SER [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:206111] LQF [cytosol] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208384] kuzbanian-mediated cleavage of Drosophila Notch
modified	[InstanceEdit:208585] Williams, MG, 2006-09-21 16:16:03 [InstanceEdit:216332] Williams, MG, 2008-03-13 17:09:58 [InstanceEdit:386960] Williams, MG, 2008-11-27 15:03:15 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	KUZ cleaves N at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD
output	[Complex:207037] Fucosylated NECD:UBI-P63E:DL/SER [plasma membrane] [Drosophila melanogaster] [Complex:206888] KUZ:NEXT [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:206111] LQF [cytosol] [Drosophila melanogaster]
precedingEvent	[Reaction:209378] The metalloprotease KUZ binds to N in the plasma membrane [Drosophila melanogaster] [Reaction:209319] LQF interacts with ubiquitinated DL/SER initiating ligand trans-endocytosis [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8906195] R-DME-209287.1
summation	[Summation:216330] The metalloprotease Kuzbanian (KUZ) cleaves the S2 site of t...
(hasEvent)	[Pathway:209369] DL/SER endocytosis and N cleavage [Drosophila melanogaster]
(precedingEvent)	[Reaction:209277] Endocytosis into the ligand's cell of the ubiquitinated DL/SER bound NECD complex [Drosophila melanogaster]
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No pathways have been reviewed or authored by KUZ cleaves N at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD (209287)