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Details on Person The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm

Class:Id	Reaction:209285
_displayName	The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm
_doRelease	TRUE
_timestamp	2012-03-01 11:27:03
authored	[InstanceEdit:386943] Williams, MG, 2006-09-21 16:49:12
catalystActivity	[CatalystActivity:208947] aspartic-type endopeptidase activity of gamma-secretase [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205681] Williams, MG, 2006-09-21 15:05:28
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
figure	[Figure:208653] /figures/DrosNotch17A.jpg
input	[EntityWithAccessionedSequence:205889] NEXT1 [plasma membrane] [Mus musculus]
literatureReference	[LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [LiteratureReference:163911] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
modified	[InstanceEdit:208585] Williams, MG, 2006-09-21 16:16:03 [InstanceEdit:209281] Williams, MG, 2006-10-24 12:43:32 [InstanceEdit:209093] Williams, MG, 2007-07-12 09:35:45 [InstanceEdit:350538] Williams, MG, 2008-05-19 14:41:26 [InstanceEdit:386963] Williams, MG, 2008-11-27 15:33:38 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:2063933] Orlic-Milacic, M, 2012-01-16 [InstanceEdit:2122946] Orlic-Milacic, M, 2012-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm
output	[EntityWithAccessionedSequence:206107] N1' [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:205738] mNICD1 [cytosol] [Mus musculus]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:2158236] R-MMU-209285.2
summation	[Summation:2063924] Based on studies of presenilin-1 (Psen1) deficient mouse emb...
(hasEvent)	[Pathway:209467] Notch (N) pathway - Inferred Events
(inferredFrom)	[Reaction:157353] NEXT1 is cleaved to produce NICD1 [Homo sapiens] [Reaction:209189] The transmembrane complex gamma-secretase cleaves NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm [Drosophila melanogaster] [Reaction:9980918] Gamma-secretase cleaves NEXT1 yielding NICD1 [Homo sapiens]
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