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Details on Person N-HH binds to the transmembrane HSPG proteins

Class:Id	Reaction:209272
_displayName	N-HH binds to the transmembrane HSPG proteins
_doRelease	TRUE
_timestamp	2018-03-09 00:15:14
authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:205626] Williams, MG, 2006-12-08 11:30:45
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:216213] /figures/DrosHHB04.jpg
input	[EntityWithAccessionedSequence:205888] N-HH [extracellular region] [Drosophila melanogaster] [DefinedSet:206547] HSPG [plasma membrane] [Drosophila melanogaster]
literatureReference	[LiteratureReference:216214] Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan [LiteratureReference:208282] Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process [LiteratureReference:216178] Functions of heparan sulfate proteoglycans in cell signaling during development [LiteratureReference:216373] A freely diffusible form of Sonic hedgehog mediates long-range signalling [LiteratureReference:216195] Lipoprotein particles are required for Hedgehog and Wingless signalling [LiteratureReference:216378] Patched, the receptor of Hedgehog, is a lipoprotein receptor
modified	[InstanceEdit:216199] Williams, MG, 2008-03-11 15:41:17 [InstanceEdit:216370] Williams, MG, 2008-03-14 16:13:34 [InstanceEdit:350533] Williams, MG, 2008-05-19 14:34:54 [InstanceEdit:386960] Williams, MG, 2008-11-27 15:03:15 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	N-HH binds to the transmembrane HSPG proteins
output	[Complex:207018] N-HH:HSPG [plasma membrane] [Drosophila melanogaster]
precedingEvent	[Reaction:209271] N-HH moves from the cytosol to the extracellular region [Drosophila melanogaster] [Reaction:209357] N-HH is palmitoylated by RASP [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8892698] R-DME-209272.4
summation	[Summation:206459] N-HH movement between cells is facilitated by the glypicans ...
(hasEvent)	[Pathway:209471] Formation and transport of the N-HH ligand [Drosophila melanogaster]
(precedingEvent)	[Reaction:209178] N-HH binds to PTC receptor complex [Drosophila melanogaster]
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No pathways have been reviewed or authored by N-HH binds to the transmembrane HSPG proteins (209272)