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Details on Person Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5

Class:Id	Reaction:209240
_displayName	Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5
_doRelease	TRUE
_timestamp	2018-03-09 00:11:11
authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
catalystActivity	[CatalystActivity:208893] protein serine/threonine kinase activity of UEV1A:BEN:IAP2:UBI-P63E:TAB2:Phospho TAK1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:358133] /figures/DrosTollImdC50.jpg
inferredFrom	[Reaction:209379] Activated human phosphorylated TAK1 kinase phosphorylates and activates IKKB dimer [Homo sapiens]
input	[Complex:206628] KEY:IRD5 dimer:KEY [cytosol] [Drosophila melanogaster] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:208348] Immune activation of NF-kappaB and JNK requires Drosophila TAK1
modified	[InstanceEdit:214122] Williams, MG, 2008-02-26 11:51:11 [InstanceEdit:358126] Williams, MG, 2008-06-19 09:29:42 [InstanceEdit:372363] Williams, MG, 2008-06-23 10:13:54 [InstanceEdit:386957] Williams, MG, 2008-11-27 14:37:44 [InstanceEdit:5263596] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024533] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5
output	[Complex:206633] KEY:Phospho IRD5 dimer:KEY [cytosol] [Drosophila melanogaster] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:209320] Activated TAK1 kinase is autophosphorylated [Drosophila melanogaster] [Reaction:209289] TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8903856] R-DME-209240.4
summation	[Summation:206440] IRD5 is phosphorylated and activated by phosphorylated TAK1 ...
(hasEvent)	[Pathway:209447] Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY [Drosophila melanogaster]
(precedingEvent)	[Reaction:209227] Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex' [Drosophila melanogaster] [Reaction:214398] Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' [Drosophila melanogaster] [Pathway:214399] Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' [Drosophila melanogaster]
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