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Details on Person Human SOS1 stimulates nucleotide exchange of Ras:GDP complex

Class:Id	Reaction:209229
_displayName	Human SOS1 stimulates nucleotide exchange of Ras:GDP complex
_doRelease	FALSE
_timestamp	2016-07-15 23:48:57
authored	[InstanceEdit:386944] Williams, MG, 2007-10-26 16:49:12
catalystActivity	[CatalystActivity:208896] guanyl-nucleotide exchange factor activity of SOS1:Ras:GDP [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205618] Williams, MG, 2007-10-30 11:44:05
figure	[Figure:947877] /figures/DrosRasRafERKA04.jpg
input	[Complex:206629] SOS1:Ras:GDP [cytosol] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:187761] The structural basis of the activation of Ras by Sos [LiteratureReference:208274] Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins
modified	[InstanceEdit:350513] Williams, MG, 2008-05-19 14:20:19 [InstanceEdit:386959] Williams, MG, 2008-11-27 14:56:57 [InstanceEdit:947989] Williams, MG, 2010-09-14 [InstanceEdit:948073] Williams, MG, 2010-09-16 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Human SOS1 stimulates nucleotide exchange of Ras:GDP complex
output	[Complex:206953] SOS1:Ras:GTP [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8881429] R-HSA-209229.1
summation	[Summation:948063] In humans, the Ras guanine-nucleotide exchange factor, Son o...
(hasEvent)	[Pathway:481001] Ras/Raf/ERK pathway - Inferred Events
(inferredFrom)	[Reaction:209219] SOS stimulates nucleotide exchange of RAS85D:GDP complex (SEV) [Drosophila melanogaster] [Reaction:379233] SOS stimulates nucleotide exchange of RAS85D:GDP complex (EGFR) [Drosophila melanogaster] [Reaction:443087] SOS stimulates nucleotide exchange of RAS85D:GDP complex (TOR) [Drosophila melanogaster] [Reaction:443195] SOS stimulates nucleotide exchange of RAS85D:GDP complex (FGFR) [Drosophila melanogaster] [Reaction:449478] SOS stimulates nucleotide exchange of RAS85D:GDP complex (PVR) [Drosophila melanogaster] [Reaction:508435] SOS stimulates nucleotide exchange of RAS85D:GDP complex [Drosophila melanogaster]
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No pathways have been reviewed or authored by Human SOS1 stimulates nucleotide exchange of Ras:GDP complex (209229)