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Details on Person DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)

Class:Id	Reaction:209226
_displayName	DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)
_doRelease	TRUE
_timestamp	2012-05-31 09:40:29
authored	[InstanceEdit:386943] Williams, MG, 2006-09-21 16:49:12
catalystActivity	[CatalystActivity:208911] ubiquitin-protein transferase activity of NEUR/MIB1 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205681] Williams, MG, 2006-09-21 15:05:28
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
entityOnOtherCell	[DefinedSet:206545] DL/SER [plasma membrane] [Drosophila melanogaster] [DefinedSet:206587] NEUR/MIB1 [cytosol] [Drosophila melanogaster] [DefinedSet:206204] UBI-P63E [cytosol] [Drosophila melanogaster]
figure	[Figure:208733] /figures/DrosNotch05A.jpg
input	[Complex:207038] Fucosylated N:DL/SER [plasma membrane] [Drosophila melanogaster] [DefinedSet:206204] UBI-P63E [cytosol] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208262] The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta [LiteratureReference:208089] Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila [LiteratureReference:208396] The interplay between DSL proteins and ubiquitin ligases in Notch signaling [LiteratureReference:208133] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta
modified	[InstanceEdit:208585] Williams, MG, 2006-09-21 16:16:03 [InstanceEdit:216332] Williams, MG, 2008-03-13 17:09:58 [InstanceEdit:386957] Williams, MG, 2008-11-27 14:37:44 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:2122946] Orlic-Milacic, M, 2012-02-14 [InstanceEdit:2268946] D'Eustachio, P, 2012-05-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)
output	[Complex:206647] Fucosylated N:UBI-P63E:DL/SER [plasma membrane] [Drosophila melanogaster]
precedingEvent	[Reaction:209323] Notch ligand (DL/SER) in the plasma membrane of an adjacent cell binds to N [Drosophila melanogaster] [Reaction:209305] Full-length fucosylated N transports from the trans-golgi to the plasma membrane [Drosophila melanogaster] [Reaction:209358] Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription [Drosophila melanogaster]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:2294766] R-DME-209226.2
summation	[Summation:216337] The E3 ubiquitin ligases Neuralized (NEUR) or Mind Bomb 1 (M...
(hasEvent)	[Pathway:209369] DL/SER endocytosis and N cleavage [Drosophila melanogaster]
(inferredFrom)	[Reaction:1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 [Homo sapiens] [Reaction:2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 [Homo sapiens] [Reaction:9013069] Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 [Homo sapiens] [Reaction:9980902] Mind bomb 1 (MIB1) ubiquitinates DLL4 in DLL4:NOTCH1 [Homo sapiens]
(precedingEvent)	[Reaction:209319] LQF interacts with ubiquitinated DL/SER initiating ligand trans-endocytosis [Drosophila melanogaster]
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No pathways have been reviewed or authored by DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1) (209226)