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Details on Person The transmembrane complex gamma-secretase cleaves NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm

Class:Id	Reaction:209189
_displayName	The transmembrane complex gamma-secretase cleaves NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm
_doRelease	FALSE
_timestamp	2016-07-15 23:49:56
authored	[InstanceEdit:386943] Williams, MG, 2006-09-21 16:49:12
catalystActivity	[CatalystActivity:208929] aspartic-type endopeptidase activity of gamma-secretase [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205681] Williams, MG, 2006-09-21 15:05:28
figure	[Figure:208532] /figures/DrosNotch10A.jpg
inferredFrom	[Reaction:209285] The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm [Mus musculus]
input	[Complex:206888] KUZ:NEXT [plasma membrane] [Drosophila melanogaster]
literatureReference	[LiteratureReference:159104] Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos [LiteratureReference:208210] Presenilin is required for activity and nuclear access of Notch in Drosophila [LiteratureReference:208327] The role of presenilin cofactors in the gamma-secretase complex
modified	[InstanceEdit:208585] Williams, MG, 2006-09-21 16:16:03 [InstanceEdit:209312] Williams, MG, 2006-10-24 12:44:58 [InstanceEdit:209093] Williams, MG, 2007-07-12 09:35:45 [InstanceEdit:216332] Williams, MG, 2008-03-13 17:09:58 [InstanceEdit:386963] Williams, MG, 2008-11-27 15:33:38 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	The transmembrane complex gamma-secretase cleaves NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm
output	[Complex:206958] KUZ:N' [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:205705] NICD [cytosol] [Drosophila melanogaster]
precedingEvent	[Reaction:209277] Endocytosis into the ligand's cell of the ubiquitinated DL/SER bound NECD complex [Drosophila melanogaster] [Reaction:209287] KUZ cleaves N at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8907762] R-DME-209189.1
summation	[Summation:216328] The S3 site of the NEXT part of Notch (N) recptor is cleaved...
(hasEvent)	[Pathway:209369] DL/SER endocytosis and N cleavage [Drosophila melanogaster]
(precedingEvent)	[Reaction:209284] NICD transports from the cytosol to the nucleus [Drosophila melanogaster]
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No pathways have been reviewed or authored by The transmembrane complex gamma-secretase cleaves NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm (209189)