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Details on Person ARM displaces GRO and binds to PAN which activates transcription

Class:Id	Reaction:209181
_displayName	ARM displaces GRO and binds to PAN which activates transcription
_doRelease	TRUE
_timestamp	2018-03-09 00:10:54
authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:205630] Williams, MG, 2006-06-28 10:48:14
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:208743] /figures/BDrosWing26.jpg
input	[Complex:206798] GRO:PAN [nucleoplasm] [Drosophila melanogaster] [Complex:206851] LGS:ARM:PYGO [nucleoplasm] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208112] Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex [LiteratureReference:208104] Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins [LiteratureReference:208192] A complex of Armadillo, Legless, and Pygopus coactivates dTCF to activate wingless target genes [LiteratureReference:208367] Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
modified	[InstanceEdit:205613] Williams, MG, 2006-07-20 14:47:06 [InstanceEdit:209182] Williams, MG, 2006-09-21 15:28:11 [InstanceEdit:208731] Williams, MG, 2006-09-22 14:12:19 [InstanceEdit:206331] Williams, MG, 2006-10-24 13:03:16 [InstanceEdit:350487] Williams, MG, 2008-05-19 14:04:01 [InstanceEdit:386957] Williams, MG, 2008-11-27 14:37:44 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024532] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ARM displaces GRO and binds to PAN which activates transcription
output	[Complex:206729] PAN:LGS:ARM:PYGO [nucleoplasm] [Drosophila melanogaster] [EntityWithAccessionedSequence:205750] GRO [nucleoplasm] [Drosophila melanogaster]
precedingEvent	[Reaction:209322] In the absence of ARM, GRO binds to PAN and inhibits transcription [Drosophila melanogaster] [Reaction:209297] PYGO binds to the LGS:ARM complex [Drosophila melanogaster] [Reaction:209177] LGS:ARM complex transports from the cytosol to the nucleus [Drosophila melanogaster] [Reaction:209332] LGS dissociates from the PYGO complex [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8914536] R-DME-209181.4
summation	[Summation:206506] Armadillo (ARM) in its complex binds to Pangolin (PAN) and t...
(hasEvent)	[Pathway:209421] Transcription activation by ARM [Drosophila melanogaster]
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