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Details on Person RL kinase is phosphorylated and activated by phosphorylated DSOR1 kinase and dissociates from KSR

Class:Id	Reaction:209164
_displayName	RL kinase is phosphorylated and activated by phosphorylated DSOR1 kinase and dissociates from KSR
_doRelease	FALSE
_timestamp	2017-06-27 17:38:00
authored	[InstanceEdit:386949] Williams, MG, 2008-10-09 16:49:12
catalystActivity	[CatalystActivity:208949] protein serine/threonine/tyrosine kinase activity of RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho (4 sites) PHL:Phospho KSR:14-3-3epsilon dimer:AVE:Phospho DSOR1:CK2:PAR-1:PP2A [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205618] Williams, MG, 2007-10-30 11:44:05
figure	[Figure:947876] /figures/DrosRasRafERKA46.jpg
input	[EntityWithAccessionedSequence:205703] RL [cytosol] [Drosophila melanogaster] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:208096] Biochemical characterization of rolledSem, an activated form of Drosophila mitogen-activated protein kinase [LiteratureReference:208170] Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry [LiteratureReference:208393] C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 [LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites [LiteratureReference:208164] Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression
modified	[InstanceEdit:386962] Williams, MG, 2008-11-27 15:15:51 [InstanceEdit:947989] Williams, MG, 2010-09-14 [InstanceEdit:948035] Williams, MG, 2010-09-15 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
name	RL kinase is phosphorylated and activated by phosphorylated DSOR1 kinase and dissociates from KSR
output	[EntityWithAccessionedSequence:206254] Phospho (2 sites) RL [cytosol] [Drosophila melanogaster] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:209335] Activated PHL kinase domain phosphorylates DSOR1 kinase and activates it [Drosophila melanogaster] [BlackBoxEvent:209299] PHL kinase domain is phosphorylated in its activation segment and activated by an unknown kinase [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8915207] R-DME-209164.1
summation	[Summation:206451] Activated Downstream of Raf1 (DSOR1) kinase phosphorylates R...
(hasEvent)	[Pathway:480996] Activation of RL kinase [Drosophila melanogaster]
(precedingEvent)	[Reaction:209186] Phosphorylated RL kinase binds to PTP-ER phosphatase [Drosophila melanogaster] [Reaction:209197] Phosphorylated RL kinase binds to MKP3 phosphatase [Drosophila melanogaster] [Reaction:209198] Phosphorylated and unphosphorylated RL kinase forms a hemiactive dimer [Drosophila melanogaster] [Reaction:209251] Phosphorylated RL kinase forms a homodimer [Drosophila melanogaster] [Pathway:209264] Phosphorylated RL kinase forms a dimer [Drosophila melanogaster] [Reaction:947726] Phosphorylated RL kinase binds to LK6 kinase [Drosophila melanogaster] [Reaction:947853] S6KII kinase binds to phosphorylated RL kinase [Drosophila melanogaster]
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