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Details on Person ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane

Class:Id	Reaction:209141
_displayName	ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane
_doRelease	TRUE
_timestamp	2018-03-09 00:17:51
authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:358188] /figures/DrosTollImdC06.jpg
input	[Complex:206793] ProSPZ:SPZ dimer [extracellular region] [Drosophila melanogaster] [EntityWithAccessionedSequence:206218] TL [plasma membrane] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208301] Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand [LiteratureReference:358180] Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Sp�tzle
modified	[InstanceEdit:214886] Williams, MG, 2008-02-26 12:31:57 [InstanceEdit:358179] Williams, MG, 2008-06-19 09:36:49 [InstanceEdit:372363] Williams, MG, 2008-06-23 10:13:54 [InstanceEdit:386962] Williams, MG, 2008-11-27 15:15:51 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane
output	[Complex:206655] SPZ dimer:TL [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:205949] ProSPZ [extracellular region] [Drosophila melanogaster] [EntityWithAccessionedSequence:205949] ProSPZ [extracellular region] [Drosophila melanogaster]
precedingEvent	[Reaction:209130] Full-length SPZ dimer is cleaved by EA/SPE serine protease [Drosophila melanogaster] [Reaction:214956] Full-length EA is cleaved by SNK serine protease [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8929891] R-DME-209141.4
summation	[Summation:206469] On binding to the Toll (TL) receptor ectodomain, Spatzle (SP...
(hasEvent)	[Pathway:209442] Formation of the trans-membrane 'signalling complex' [Drosophila melanogaster]
(precedingEvent)	[Reaction:209076] SPZ dimer bound TL dimerises at the plasma membrane [Drosophila melanogaster]
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No pathways have been reviewed or authored by ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (209141)