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Details on Person Full-length SPZ dimer is cleaved by EA/SPE serine protease

Class:Id	Reaction:209130
_displayName	Full-length SPZ dimer is cleaved by EA/SPE serine protease
_doRelease	TRUE
_timestamp	2018-03-09 00:14:05
authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
catalystActivity	[CatalystActivity:208878] serine-type endopeptidase activity of EA/SPE [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:358137] /figures/DrosTollImdC04.jpg
input	[Complex:206598] SPZ full-length dimer [extracellular region] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208301] Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand [LiteratureReference:208051] A processed form of the Spatzle protein defines dorsal-ventral polarity in the Drosophila embryo [LiteratureReference:208180] Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity [LiteratureReference:208355] A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity [LiteratureReference:208033] Expression and regulation of Spatzle-processing enzyme in Drosophila
modified	[InstanceEdit:209119] Williams, MG, 2007-07-12 10:23:24 [InstanceEdit:214886] Williams, MG, 2008-02-26 12:31:57 [InstanceEdit:358134] Williams, MG, 2008-06-19 09:30:42 [InstanceEdit:372363] Williams, MG, 2008-06-23 10:13:54 [InstanceEdit:386957] Williams, MG, 2008-11-27 14:37:44 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024533] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Full-length SPZ dimer is cleaved by EA/SPE serine protease
output	[Complex:206793] ProSPZ:SPZ dimer [extracellular region] [Drosophila melanogaster]
precedingEvent	[Reaction:214956] Full-length EA is cleaved by SNK serine protease [Drosophila melanogaster] [Reaction:214953] Full-length SNK is cleaved by GD serine protease [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8926850] R-DME-209130.4
summation	[Summation:206412] In dorsoventral patterning, the trypsin-like serine protease...
(hasEvent)	[Pathway:209442] Formation of the trans-membrane 'signalling complex' [Drosophila melanogaster]
(precedingEvent)	[Reaction:209141] ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane [Drosophila melanogaster] [Reaction:209376] SPN27A binds to and inhibits EA protease activity [Drosophila melanogaster]
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